Activation by two recombinant naturally occurring myeloid proteins of an anti-inflammatory and anti-hypoxic pathway
S100 proteins are small calcium-binding proteins that are found at high levels in the extracellular milieu during inflammatory conditions. The UIC inventor has discovered that these proteins possess significant anti-inflammatory and anti-hypoxic activity. It was also shown that S100 proteins inhibit the activation of peripheral neutrophils by activating a specific type of PKC known for its anti-inflammatory activity, and have a protective effect against hypoxia. The two proteins are good potential therapeutic targets for the treatment of deleterious inflammation especially in association with hypoxia / ischemia. The inventor has also shown through in vivo experiments that they can ameliorate cutaneous wound healing in an animal model of hypoxia impaired wounds.